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The proteome of the protozoan parasite Leishmania

Reference	GAN13076
Principal Investigator / Supervisor	Professor Michael Dunn
Co-Investigators / Co-Supervisors	Dr Alastair Ivens
Institution	King's College London
Department	Institute of Psychiatry
Funding type	Research
Value (£)	189,678
Status	Completed
Type	Research Grant
Start date	01/01/2001
End date	30/09/2005
Duration	57 months

Abstract

Leishmania, a flagellated protozoan parasite, is the causative agent of the leishmaniases group of diseases. There is currently no effective vaccine, and drug treatment is limited to toxic, expensive antimonials. The 35Mb genome of the reference strain (Leishmania major Friedlin) is currently being sequenced as part of a world-wide consortium; it is estimated that there are 9800 genes, 40 per cent of which are novel. As the organism does not exhibit a sexual cycle, and gene expression is regulated post-transcriptionally, we propose to use proteomics to elucidate the molecular changes that occur as Leishmania parasites progress through the life-cycle stages in vitro. Using 2D gel electrophoresis, quantitative computer analysis and mass spectrometry, proteins that exhibit marked changes will be identified and characterised, and their suitability as targets for drug design and/or vaccines assessed.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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