Award details

A genomics approach to neuromuscular function in Drosophila

Reference	GAN13071
Principal Investigator / Supervisor	Professor Cahir O'Kane
Co-Investigators / Co-Supervisors	Dr Iain Robinson
Institution	University of Cambridge
Department	Genetics
Funding type	Research
Value (£)	224,416
Status	Completed
Type	Research Grant
Start date	01/06/2000
End date	31/07/2003
Duration	38 months

Abstract

We have recently completed a screen for Drosophila insertion mutants that show substantial paralysis of embryonic body wall muscles. Analysis of a sample of these shows that, as expected, they are predominantly affecting genes that are required for neuromuscular development or function. These mutants represent the contribution of a large fraction of the genome to basic neuromuscular function. Therefore, we will undertake genetic characterisation of the lines, to identify the genes that are affected in as many as possible of the lines. We also will undertake basic phenotypic characterisation of the lines, to obtain an idea of the cellular basis for the defects. A few genes with a role in synapse function will be studied in more depth.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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