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Identification and functional characterisation of novel genes involved in the adaptive response of peripheral nervous system to injury
Reference
GAN13066
Principal Investigator / Supervisor
Professor David Wynick
Co-Investigators /
Co-Supervisors
Professor Patrick Headley
Institution
University of Bristol
Department
Physiology and Pharmacology
Funding type
Research
Value (£)
138,992
Status
Completed
Type
Research Grant
Start date
01/01/2001
End date
01/01/2003
Duration
24 months
Abstract
The neuropeptide galanin is expressed at low levels in normal adult dorsal root ganglia (DRG) and up-regulates markedly following nerve injury. We have knocked out galanin demonstrating a novel survival and trophic role for galanin in the embryonic and adult DRG. The loss of a subset of small nociceptors almost completely abolishes the symptoms of neuropathic pain. This application will bring together cutting-edge molecular genetics and behavioural physiology, allowing us to identify novel genes that are the up- and down-stream components of the galanin-receptor interaction. These studies will further define the molecular cascades that mediate nerve regeneration and pathological nociceptive responses.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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