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Genetic control of learning behaviour: identification of downstream genes by zif/268
Reference
GAN13063
Principal Investigator / Supervisor
Professor Brian Morris
Co-Investigators /
Co-Supervisors
Dr Paul Burr
Institution
University of Glasgow
Department
Institute of Biomedical & Life Sciences
Funding type
Research
Value (£)
304,440
Status
Completed
Type
Research Grant
Start date
01/11/2000
End date
01/01/2004
Duration
38 months
Abstract
The transcription factor zif/268 (egr1) is induced in many models of learning behaviour across many animal species. However, the target genes which it affects, which are likely to be responsible for maintaining the altered neuronal network activity, have not been identified. This project will use differential display and gene arrays to identify the genes whose level of expression is altered by zif/268 induction in rat hippocampal neurones (involved in spatial learning) and the HCN-1 neuronal cell line. The results should dramatically increase our understanding of learning mechanisms at the molecular and cellular level.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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