Award details

Clock gene expression circadian behaviour and ocular clock function in retinal transgenics

Reference	GAN13052
Principal Investigator / Supervisor	Professor Russell Foster
Co-Investigators / Co-Supervisors
Institution	Imperial College London
Department	Dept of Medicine
Funding type	Research
Value (£)	396,256
Status	Completed
Type	Research Grant
Start date	01/01/2001
End date	01/01/2004
Duration	36 months

Abstract

Models for circadian clock function in mammals are based largely upon in vitro cellular assays. Few studies have related patterns of clock gene expression to specific features of the circadian phenotype. We propose novel approaches to this problem by utilising a number of well defined retinal transgenic and mutant mice in which we can place patterns of clock gene expression into a functional context. We address two related questions: What is the relationship between light, clock gene expression, circadian behaviour, and retinal photoreceptors? and How are ocular circadian rhythms generated and regulated by light? The experiments associated with these questions will help us to define the role of putative clock genes in the regulation and generation of circadian rhythms within the suprachiasmatic nuclei (SCN) and retina.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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