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Phenotypic adaptation to temperature: genomic and reverse genetic approaches to the underlying mechanisms

Reference	GAN13050
Principal Investigator / Supervisor	Professor Andrew Cossins
Co-Investigators / Co-Supervisors	Dr Andrew Gracey
Institution	University of Liverpool
Department	Sch of Biological Sciences
Funding type	Research
Value (£)	189,832
Status	Completed
Type	Research Grant
Start date	01/09/2000
End date	02/05/2004
Duration	44 months

Abstract

Whole animal phenotypes respond adaptively to altered conditions, improving physiological performance and resisting debilitating damage and mortality. The underlying responses are poorly described or integrated at the whole animal level, and the regulatory mechanisms are undefined. We propose to use whole genome microarray analysis of the model nematode worm, C. elegans, to define comprehensively the genes and multigene systems involved in responses to altered growth temperature. Knockout mutants of critical genes will be isolated and their role in adaptation of the thermal phenotype assessed to demonstrate their central role. Initial experiments will focus upon a suite of desaturases that increase the unsaturation of membrane lipids in response to chronic cold. Effects of knockout upon acquired cold tolerance and modified lipid composition will be determined.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Genomics in Animal Function Initiative (GAN) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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