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Wnt signalling function in Xenopus forebrain development
Reference
G20373
Principal Investigator / Supervisor
Professor Stefan Hoppler
Co-Investigators /
Co-Supervisors
Institution
University of Aberdeen
Department
Biomedical Sciences
Funding type
Research
Value (£)
186,828
Status
Completed
Type
Research Grant
Start date
01/07/2004
End date
30/06/2007
Duration
36 months
Abstract
Wnt signalling provides a central mechanism for organising the vertebrate embryo. We have previously shown that Wnt signalling is necessary in Xenopus during early neural development for patterning the anterior-posterior axis. Surprisingly, our recent preliminary data suggest the Wnt signalling also patterns the anterior-posterior neural axis during a second, later stage of development. We propose to use our recently developed inducible expression method in transgenic Xenopus embryos to overexpress activating and inhibiting gene constructs, as well as using morpholino of oligonucleotides as gene-specific inhibitors, in order to elucidate the function of individual Wnt ligands and the Wnt signalling pathway at these distinct stages of neural development.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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