BBSRC Portfolio Analyser
Award details
Morphogenetic movements and cell fate specification during the formation of the vertebrate inner ear
Reference
G20323
Principal Investigator / Supervisor
Professor Andrea Streit
Co-Investigators /
Co-Supervisors
Institution
King's College London
Department
Craniofacial Dev Orthodon and Microbiol
Funding type
Research
Value (£)
236,447
Status
Completed
Type
Research Grant
Start date
01/03/2004
End date
29/02/2008
Duration
48 months
Abstract
Coordination of morphogenetic movements with cell fate determination is critical for establishing the complex architecture of specialised organs. Here we will characterise the movements of single precursor cells that will contribute to the inner ear and associated ganglia using lipophilic dyes or reporter constructs and time-lapse filming. The molecular mechanisms that control these movements will be investigated with a combination of gene misexpression, time-lapse microscopy and analysis of marker genes. In particular, we will study the role of Eph-ephrin, Notch and Wnt signalling in initiating radial convergence of otic cells and in segregating neural crest and otic precursors. The role of Pax2 in otic specification will also be assessed.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search