Award details

Identification of the chicken talpid3 mutant gene and its target genes

Reference	G20297
Principal Investigator / Supervisor	Professor David Burt
Co-Investigators / Co-Supervisors
Institution	The Roslin Institute
Department	Genetics and Genomics
Funding type	Research
Value (£)	175,891
Status	Completed
Type	Research Grant
Start date	22/01/2004
End date	21/01/2008
Duration	48 months

Abstract

We will build on recent progress in mapping the chicken talpid3 mutation and identify the talpid3gene. This gene is of fundamental importance because, in this mutant, all Hedgehog-signalling is disrupted. Hedgehogs are a major class of extracellular signalling molecules, implicated in cell differentiation and survival both in embryos and tumours. Talpid3 limbs have many digits with no anterior-posterior pattern. We will exploit chicken genome resources and microarray technology to make a comprehensive comparison of patterns of gene expression in normal and talpid3 limb buds. This will identify target genes downstream of the talpid3 gene and also identify new genes involved in anterior-posterior limb patterning. (Joint with grant number 20298).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G20298 Identification of the chicken talpid3 mutant gene and its target genes

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