BBSRC Portfolio Analyser
Award details
Control of histone methylation by Polycomb-group genes in Arabidopsis
Reference
G20266
Principal Investigator / Supervisor
Dr Justin Goodrich
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Inst of Cell and Molecular Biology
Funding type
Research
Value (£)
194,945
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
31/12/2006
Duration
39 months
Abstract
The expression of homeotic genes specifying cell fate is regulated by Polycomb-group (Pc-G) proteins in plants and animals. In plants, cell fates are easier to reprogram than in animals, suggesting that epigenetic switches may be less stable. In animals Polycomb-group proteins (Pc-G) have recently been shown to methylate lysine residues in histone H3 tails. We propose to characterise the global and local effects of Arabidopsis Pc-G mutants on histone methylation using Western and CHiP analysis. In particular, we will use CHiP to analyse histone methylation in regulatory regions of the AGAMOUS gene, which is a target of the Pc-G member CURLY LEAF. A microarray approach will be used to identify novel targets of the Pc-G.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search