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Is translational control a mechanism for controlling neural stem cell differentiation and fate?
Reference
G20236
Principal Investigator / Supervisor
Professor Jack Price
Co-Investigators /
Co-Supervisors
Professor Steven Williams
Institution
King's College London
Department
Neuroscience
Funding type
Research
Value (£)
199,074
Status
Completed
Type
Research Grant
Start date
01/09/2004
End date
29/02/2008
Duration
42 months
Abstract
Neural stem cells are of interest because they can replace brain cells lost through disease or damage. We have no knowledge, however, of what mechanisms assure cell replacement is appropriate: i.e. that the correct cells are generated. Embryonic neurogenesis would suggest the involvement of genes that encode positional specification and cell fate. We have preliminary data to show that such genes are expressed by neural stem cells, but that their function is regulated by translational control involving the 3-prime UTR. In this study we will identify the sequences and mechanisms involved in this control, assess the specificity of the mechanisms, and attempt to discover the significance of translational control for neural stem cell biology.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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