Award details

The growth hormone pathway and the genetic control of height and weight

Reference	G20234
Principal Investigator / Supervisor	Professor D Goldstein
Co-Investigators / Co-Supervisors	Professor Tim Spector
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	384,063
Status	Completed
Type	Research Grant
Start date	06/10/2003
End date	05/09/2005
Duration	23 months

Abstract

Here we will use variation in human height and weight as a model for developing and refining methods for linkage disequilibrium-based gene mapping. Height and weight are attractive phenotypes because they have high heritability (greater than 0.6), are easy to define, and inexpensive to measure. In addition, there are appropriate candidate genes. We will use a novel multi-step programme based on linkage disequilibrium mapping to screen 25 genes from the growth hormone pathway for a minimal set of polymorphisms (haplotype tagging SNPs) that can represent the common variants in each of these candidate genes. These tagging SNPs will then be assayed in a large cohort of healthy volunteers that have been measured for height, weight, and other characteristics. The results from this study will not only improve our understanding of variation in height and weight but will also serve as an instructive model for the design and implementation of future association studies of both medical and evolutionary traits.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G20234/2 The growth hormone pathway and the genetic control of height and weight

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