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Evolution of antibiotic genes and streptomycetes: the species concept and lateral gene transfer
Reference
G20166
Principal Investigator / Supervisor
Professor Michael Goodfellow
Co-Investigators /
Co-Supervisors
Professor Alan Ward
Institution
Newcastle University
Department
Sch of Biology
Funding type
Research
Value (£)
217,461
Status
Completed
Type
Research Grant
Start date
15/02/2004
End date
14/02/2007
Duration
36 months
Abstract
Recently the potential of streptomycetes for new bioactive natural products was estimated as upwards of 100,000 new compounds yet to be discovered. The distribution of undiscovered bioactive compounds across microbial diversity, and the optimum search and discovery strategies to exploit them, depend upon the evolutionary mechanisms operating on organisms and genes. Using members of the Streptomyces violaceoruber clade and their natural product genes as a model we will determine environmental, biogeographical and phylogenetic patterns of distribution using multi-locus sequencing and micro-arrays to do comparative genomics, population biology and phylogeny, then infer evolutionary mechanisms and validate search and discovery strategies.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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