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NOV: a key regulator of stem cell proliferation survival and differentiation
Reference
G20164
Principal Investigator / Supervisor
Dr Catherine Boulter
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Genetics
Funding type
Research
Value (£)
198,532
Status
Completed
Type
Research Grant
Start date
06/01/2004
End date
05/05/2007
Duration
40 months
Abstract
Nov encodes a secreted modular protein which shares structural similarities to the IGF binding proteins and chordin, and is over-expressed in a variety of tumours. We have shown that forced expression of Nov affects proliferation, survival and differentiation of stem cells and their differentiated progeny. We hypothesise that in vivo Nov may regulate the balance between expansion of committed stem cell populations and their terminal differentiation, through interaction with extracellular signals. We aim to investigate this by expressing NOV proteins lacking specific domains in cell culture, and generating conditional knockout and deletion mouse mutants to define its roles in cell proliferation, differentiation and development.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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