Award details

Novel and effective bioassays for the characterisation and identification of pronephros patterning genes in Xenopus

Reference	G19888
Principal Investigator / Supervisor	Professor Elizabeth Jones
Co-Investigators / Co-Supervisors	Dr Karine Masse
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	394,724
Status	Completed
Type	Research Grant
Start date	22/09/2003
End date	21/09/2006
Duration	36 months

Abstract

We have identified a biological activity in anterior somites with the unique ability to induce pronephric kidney in Xenopus. We will develop the newly established techniques of transgenesis and electroporation for the study of pronephric-specific gene expression. Transgenesis combined with orthotopic grafting will establish the effects of transgenic overexpression of known kidney specific genes. Organ-specific electroporation will extend these studies to identify the full role of these genes in pronephrogenesis. We will use functional expression libraries to clone the identified somite activity together with others which affect pronephric development. We will place these genes in a genetic hierarchy explaining pronephrogenesis and patterning.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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