Award details

Clustered fox genes and the evolution of mesoderm

Reference	G19873
Principal Investigator / Supervisor	Professor Sebastian Shimeld
Co-Investigators / Co-Supervisors
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	206,021
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/01/2005
Duration	10 months

Abstract

The Fox genes encode transcription factors. We have identified a conserved cluster of Fox genes that are expressed in different subdivisions of bilaterian mesoderm. We first propose to extend our understanding of this gene cluster in the bilateria by characterising Fox gene organisation and expression in polychaetes, members of the Lophotrochozoa. Secondly, we propose to characterise Fox gene clustering and expression in Cnidaria and Ctenophora. This will allow inference of primitive organisation and function of the cluster in the bilateria, and will indicate how it evolved during the early evolution of the bilateria, giving insight into the relationship between cluster expansion and mesoderm origin and diversification.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G19873/2 Clustered fox genes and the evolution of mesoderm

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