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Dynamics of chromosome pairing during plant meiosis: the role of Asy1 an Arabidopsis protein essential for synapsis
Reference
G19864
Principal Investigator / Supervisor
Professor Chris Franklin
Co-Investigators /
Co-Supervisors
Dr G Jones
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
233,789
Status
Completed
Type
Research Grant
Start date
07/01/2004
End date
06/01/2007
Duration
36 months
Abstract
Molecular cytogenetic techniques will be used to elucidate the molecular processes that underpin the extensive reorganisation of chromatin that enables homologous chromosomes to pair in early prophase I of meiosis. We aim to study the role of the Arabidopsis protein Asy1 in early pairing events and homology searching preceding synapsis. The distribution of Asy1 in relation to homologue juxtaposition during early prophase will be investigated in fixed and living cells. How Asy1 interfaces with and regulates the spatial distribution and activity of other key meiotic proteins will be determined in WT and mutant plants. The interrelationship of these events with changes in chromatin modifications will be explored.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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