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Morphogenetic cell movements in the mouse embryo immediately after implantation
Reference
G19862
Principal Investigator / Supervisor
Professor Magdalena Zernicka-Goetz
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Genetics
Funding type
Research
Value (£)
361,609
Status
Completed
Type
Research Grant
Start date
15/04/2004
End date
14/08/2008
Duration
52 months
Abstract
Recent evidence suggests mammals acquire polarity at early embryonic stages in a process associated with extensive pre-gastrulation cell movements. We will determine, using in vivo studies, how the overall asymmetric patterns of cell movement that we previously characterised relate to distal to anterior migration of cells essential for future head development. We will further analyse how global morphogenetic cell movements are affected by loss of beta-catenin expression or by cell ablation, processes that prevent distal to anterior migration. Finally we will study the effects of spatial or temporal modulation of Wnt/beta-catenin expression on global morphogenetic movements. This study will enable us to correlate translation of polarity in the peri-implantation period to morphogenetic cell movements.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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