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Architecture of a nucleoprotein segrosome complex that mediates bacterial DNA segregation: the diminutive parFGH locus
Reference
G19857
Principal Investigator / Supervisor
Dr Finbarr Hayes
Co-Investigators /
Co-Supervisors
Dr Daniela Barilla
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
242,671
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/06/2007
Duration
45 months
Abstract
Plasmids are attractive systems for unravelling the molecular details of bacterial DNA segregation due to their inherent biological importance and because of the insights which can be provided into bacterial chromosome partition. The parFGH module of multidrug resistance plasmid TP228 is a particularly malleable system in which to dissect the DNA segregation process because of the relatively small sizes of the requisite proteins, the comparative ease with which the molecular components can be manipulated, and the progress which we have recently made in our understanding of this system. By analyzing the interactions involved in assembly of the ParFGH nucleoprotein complex, new insights into the fundamental process of DNA segregation will be provided.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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