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Identification of TGF-beta signalling targets in Drosophila on a genome-wide scale
Reference
G19755
Principal Investigator / Supervisor
Professor Hilary Ashe
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
207,621
Status
Completed
Type
Research Grant
Start date
27/01/2004
End date
26/01/2007
Duration
36 months
Abstract
A gradient of the TGF-beta signalling molecules Decapentaplegic (Dpp) and Screw (Scw) patterns the dorsal ectoderm of the Drosophila embryo by activating Smad transcription factors. Peak Dpp/Scw signalling specifies amnioserosa formation, whereas lower levels of signalling promote dorsal epidermis fates. This proposal aims to determine the genome-wide changes in transcription in response to peak Dpp/Scw signalling using DNA microarrays. From the genes identified which respond to peak Dpp/Scw signalling, loss- and gain-of-function analyses will be used to identify key genes which promote amnioserosa differentiation. Results from these studies will provide molecular detail as to how signalling molecules induce particular cell fates.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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