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Immunoglobulin-like neural adhesion molecules in the control of neuronal progenitor proliferation and differentiation

Reference	G19459
Principal Investigator / Supervisor	Professor Andrew Furley
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Centre for Development Genetics
Funding type	Research
Value (£)	224,756
Status	Completed
Type	Research Grant
Start date	01/08/2003
End date	30/09/2006
Duration	38 months

Abstract

Neural cell adhesion molecules of the L1 family (L1nCAMs) are widely documented to be involved in cell migration, axon growth and guidance and synapse formation and function. However, our recent work suggests a role for these molecules in the control of neuronal precursor proliferation and differentiation in the developing cerebullum. Here, using genetic loss- and gain-of- function approaches in vitro and in vivo, we propose to extend this work to elucidate the signalling pathways and cell contacts in which these molecules are involved. These findings may provide novel tools for the control of the behaviour of neuronal stem and precursor cells.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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