BBSRC Portfolio Analyser
Award details
siRNA: a new technology for investigating gene function in developing organs
Reference
G19227
Principal Investigator / Supervisor
Professor Jamie Davies
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Biomedical Sciences
Funding type
Research
Value (£)
177,692
Status
Completed
Type
Research Grant
Start date
01/10/2003
End date
30/09/2006
Duration
36 months
Abstract
We wish to characterise and improve a new technology for manipulating selected genes during organ development in culture. The technology, using siRNAs, offers ethical, technical and economic advantages over transgenic mice. We have pilot data that confirms its effectiveness at repressing the expression of the transcription factor WT1 in kidney development. We now wish to further characterise the ability of multiple siRNAs to work simultaneously, to enter epithelia, and to pass from cell to cell in organ culture. The outcome will be a well-characterised technique offering great advantages over current technologies, and which is likely to be directly applicable to the development of many mammalian organs and body parts.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search