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The role of IP3-mediated signalling in cell differentiation in C.elegans
Reference
G19220
Principal Investigator / Supervisor
Dr Howard Baylis
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Zoology
Funding type
Research
Value (£)
231,660
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
31/03/2006
Duration
36 months
Abstract
Intracellular signalling through inositol 1,4,5-trisphosphate (IP3) is an important and widespread mechanism for transducing cell surface signals to changes in animal biology. However the roles of IP3 signalling during development are poorly understood. We have shown that in C. elegans disruption of IP3 signalling causes embryonic lethality and a failure in the differentiation of, at least one, cell lineage. We now aim to: determine the precise nature of the developmental defects caused by ablating IP3 function, identify when and where the signal is required and identify further genes encoding the signalling mechanism. To do this we will use an integrated approach that uses genetic, transgenic, functional and physiological techniques.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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