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Definition of the mouse CNS axon regeneration transcriptome and proteome
Reference
G18986
Principal Investigator / Supervisor
Professor Ann Logan
Co-Investigators /
Co-Supervisors
Professor Martin Berry
Institution
University of Birmingham
Department
Medical Sciences - Medicine
Funding type
Research
Value (£)
486,736
Status
Completed
Type
Research Grant
Start date
01/07/2003
End date
31/01/2007
Duration
43 months
Abstract
CNS regeneration fails because the trophic environment about the axon is sub-optimal for growth. Evidence for the co-ordinated gene program regulating axon regeneration is incomplete. We aim to define the complement of CNS axon regeneration-related mRNA and proteins. We will use genomic (cDNA microarray) and proteomics (2D gel electrophoresis/mass spectrometry) techniques to compare the expression profiles of regeneration genes and proteins in axotomised neurons and also reactive glia at the lesion site in regenerating versus non-regenerating in vivo CNS injury models.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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