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Novel technology to identify and study sequence elements involved in long-range gene regulatory interactions in vivo
Reference
G18775
Principal Investigator / Supervisor
Dr Peter Fraser
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Chromatin and Gene Expression
Funding type
Research
Value (£)
214,696
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
31/03/2006
Duration
36 months
Abstract
Genetic and functional studies suggest many nuclear processes rely on regulatory interactions between distant DNA sequences. However, in the absence of direct proof the existence and nature of these interactions in vivo remains controversial and speculative. We have developed a technique to tag and analyse chromatin from specific gene loci in situ, and used it to show that the beta-globin Locus Control Region is intimately engaged in vivo with a transcribing beta-globin gene located over 50 kb away. Adaptations of this technology will be applicable to many other genes, to rapidly identify long-range regulatory elements as well as permit detailed study of the function of higher-order chromatin folding in control of diverse nuclear processes.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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