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The transcriptional response to different levels Drosophila mef2 in muscle differentiation
Reference
G18743
Principal Investigator / Supervisor
Dr Michael Taylor
Co-Investigators /
Co-Supervisors
Institution
Cardiff University
Department
School of Biosciences
Funding type
Research
Value (£)
221,052
Status
Completed
Type
Research Grant
Start date
26/08/2003
End date
25/08/2006
Duration
36 months
Abstract
In development there is much to learn of the genetic circuitry that operates downstream of patterning events to regulate cell differentiation. We will study this fundamental issue using a key transcription factor in Drosophila muscle development, Dmef2. We wish to test the idea that different muscle genes have distinct thresholds for activation by Dmef2 and then analyse the basis of these thresholds. We will identify candidate targets by microarrays using an allelic series expressing different levels of Dmef2. Our analysis of target gene enhancers will use computational methods including phylogenetically foot printing, and then we will experimentally dissect selected enhancers by mutagenesis of identified sites and in vivo expression assays.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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