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TGFb signalling during dorsal closure in Drosophila melanogaster
Reference
G18737
Principal Investigator / Supervisor
Dr Jim Bloor
Co-Investigators /
Co-Supervisors
Institution
University of Kent
Department
Sch of Biosciences
Funding type
Research
Value (£)
200,632
Status
Completed
Type
Research Grant
Start date
02/09/2003
End date
01/10/2006
Duration
37 months
Abstract
Signalling by the Drosophila TGF beta homologue Dpp is required for dorsal closure, the morphogenetic process by which the epidermis encloses the developing embryo. Phenotypic analysis suggests that the Drosophila PS3 integrin functions in Dpp signalling during this process. Vertebrate TGF beta activity can be regulated by direct integrin binding. We describe experiments designed to test our hypothesis that direct binding between PS3 and the Dpp proprotein regulates Dpp signalling during dorsal closure. Further, we test our hypothesis that short-range PS3-dependent Dpp signalling is essential for the function of leading edge filopodia.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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