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The mechanism and biological significance of RNA directed DNA methylation
Reference
G18736
Principal Investigator / Supervisor
Dr Louise Jones
Co-Investigators /
Co-Supervisors
Institution
University of York
Department
Biology
Funding type
Research
Value (£)
212,068
Status
Completed
Type
Research Grant
Start date
09/06/2003
End date
08/06/2006
Duration
36 months
Abstract
RNA silencing is a sequence-specific mechanism of RNA degradation that is conserved across kingdoms. In plants RNA silencing can also lead to the promotion of sequence-specific de novo DNA methylation and transcriptional gene silencing that is heritable. This observation challenges the central dogma that information flow is always from DNA to RNA and suggests that silencing events at the RNA and DNA level can be mechanistically linked. The aim of this proposal is to investigate the mechanism of RNA-directed DNA methylation (RdDM) through the generation and identification of RdDM-defective mutants. The genomic targets of RdDM will be identified by examining global DNA methylation in RdDM mutants compared to that of wild-type plants.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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