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The analysis of stem and progenitor cell potential at the epigenetic level
Reference
G18655
Principal Investigator / Supervisor
Professor Constanze Bonifer
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
School of Medicine
Funding type
Research
Value (£)
180,416
Status
Completed
Type
Research Grant
Start date
01/08/2003
End date
31/07/2006
Duration
36 months
Abstract
The regular regenerative renewal of tissues such as skin or blood is based on the existence of an extensive system of multi-potent somatic stem cells. It was previously thought that the different stem cell types are only able to regenerate their respective tissue system. In recent years, experiments were published that indicated tissue specific somatic stem cells may have a greater developmental potential than originally assumed. However, some of these findings were recently questioned. More basic research needs to be conducted that examines the cellular and molecular basis of stem cell potential. The experiments outlined in this proposal seek to develop experimental systems and methods that examine the epigenetic mechanism of the restriction in stem cell potential and explore ways to overcome it.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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