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Role of the Soj-SpoOJ system in chromosome segregation and the switch from proliferation to differentiation in Bacillus subtilis
Reference
G18654
Principal Investigator / Supervisor
Professor Jeffery Errington
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Sir William Dunn Sch of Pathology
Funding type
Research
Value (£)
244,340
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
31/03/2006
Duration
36 months
Abstract
The Soj-Spo0J system plays a key role in two central processes of the B. subtilis life cycle. First, it is required for stable maintenance of the replicon (i.e. the chromosome). Second, it regulates the switch from proliferative growth to spore formation, a simple but well characterised cell differentiation process. Chromosome segregation is a poorly understood problem of fundamental biological importance. The regulatory switch represents a specialisation of the spore forming bacteria, but it is illustrative of a key question of developmental biology. This proposal seeks to improve our understanding of both chromosome segregation and developmental switching, using the superb experimental tools available for B. subtilis.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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