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Analysis of cell cycle transcriptional regulation by mutation of promoter control elements in the mouse
Reference
G18650
Principal Investigator / Supervisor
Dr Roger Watson
Co-Investigators /
Co-Supervisors
Institution
Imperial College London
Department
Dept of Medicine
Funding type
Research
Value (£)
225,616
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
31/03/2006
Duration
36 months
Abstract
The objective of this study is to develop animal and cell culture models to study the role of E2F complexes in suppression of cell cycle-regulated gene expression. The B-myb promoter E2F site has been mutated in the mouse genome by gene targetting in ES cells and chimaeric mice have been obtained. This system will now be developed to study the protein complexes which assemble on the B-myb E2F site and extinguish transcription in quiescent mouse embryo fibroblasts. These studies will then be extended to analyse the significance of the E2F site in suppression of B-myb expression that characterises withdrawal from the cell cycle in animal development and cellular replicative senescence and differentiation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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