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Characterisation of SDE5 an Arabidopsis protein required for RNA silencing
Reference
G18622
Principal Investigator / Supervisor
Professor Tamas Dalmay
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Biological Sciences
Funding type
Research
Value (£)
218,012
Status
Completed
Type
Research Grant
Start date
01/04/2003
End date
01/04/2006
Duration
36 months
Abstract
RNA silencing is a basic cellular progress in fungi, plants and animals. I have identified five silencing defective (sde) mutants in Arabidopsis, and propose here to characterise the protein product of one of these, SDE5. SDE5 is of particular interest because it may pay a role in normal plant development. We will analyse the interaction of SDE5 with other proteins and with short interfering RNAs. To identify the function of SDE5 we will determine if it is required for plant development, transposon silencing, RNA induced DNA methylation and silencing mediated virus resistance. We will also establish the sub-cellular localisation and expression profile of SDE5.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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