Award details

Evolution of a unique gene arrangement in genus Entamoeba

Reference	G18391
Principal Investigator / Supervisor	Dr Bart Barrell
Co-Investigators / Co-Supervisors	Dr Charles Clark
Institution	Wellcome Trust Sanger Institute
Department	Wellcome Trust Sanger Institute Department
Funding type	Research
Value (£)	83,428
Status	Completed
Type	Research Grant
Start date	01/10/2002
End date	30/09/2004
Duration	24 months

Abstract

A genome project for Entamoeba histolytica is underway, and one early finding is a unique tRNA gene organisation. Almost all are found in long tandem arrays of repeat units containing one to five tRNA genes separated from each other by short, tandemly repeated, non coding DNA. Not only is the organisation unique but the number of genes for most tRNA isoacceptor types is unprecedented, ranging from dozens to hundreds. The origin and function of these arrays is totally unknown. This study will investigate the organisation of tRNA genes in other species in the genus of known relationships with a view to better understanding how, and perhaps gaining an insight into why, this unique organisation arose. (Joint with grant 18390).

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G18390 Evolution of a unique gene arrangement in the genus Entamoeba

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