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The role of PTEN and its relationship with Stat3 in mammary gland development
Reference
G18086
Principal Investigator / Supervisor
Professor Christine Watson
Co-Investigators /
Co-Supervisors
Dr Katherine Abell
,
Dr Richard Clarkson
Institution
University of Cambridge
Department
Pathology
Funding type
Research
Value (£)
279,560
Status
Completed
Type
Research Grant
Start date
01/03/2003
End date
31/03/2006
Duration
37 months
Abstract
The tumour suppressor, PTEN, regulates growth, differentiation and apoptosis in normal embryonic development; processes that are particularly important in adult mammary gland developmental cycles. Using microarrays, we found that a change in PTEN expression coincides with a switch from Stat5 to Stat3 activity, and the onset of apoptosis, in mammary gland. Furthermore, PTEN was directly and reciprocally regulated by Stats3 and 5 in vitro. We aim to formally establish the link between PTEN, Stats and the regulation of apoptosis in mammary gland. We have generated a conditional knockout of Stat3 and will cross these knockout animals with floxed PTEN mice to further delineate the molecular pathways that regulate the induction of apoptosis.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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