Award details

Chemotactic cell movement during gastrulation in the chick

Reference	G18071
Principal Investigator / Supervisor	Professor Kees Weijer
Co-Investigators / Co-Supervisors	Professor Andrea Munsterberg
Institution	University of Dundee
Department	College of Life Sciences
Funding type	Research
Value (£)	210,540
Status	Completed
Type	Research Grant
Start date	01/09/2003
End date	31/08/2006
Duration	36 months

Abstract

We investigate the control of cell movement during gastrulation in chick embryos. We have shown that the movement of cells emerging from the primitive streak is guided both by positive and negative chemotaxis to FGFs as well as other unknown chemo-attractants. We will interfere with in-vivo FGF signalling by locally over expressing FGFs and by depleting specific FGFs with soluble FGF specific receptor fragments and neutralising antibodies. We will express GFP tagged dominant negative and active receptors and downstream signalling components to investigate the signalling pathways leading from FGF receptors to directed cell movement. We will screen other candidate molecules, Wnts, PDGFs, VEGFs and SLITs for chemo- attractant and or repellent activity in-vitro and in-vivo and initiate expression cloning experiments to identify novel attractive and repulsive molecules.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search