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The genetic control of the undifferentiated phenotype of human embryonic stem cells
Reference
G17918
Principal Investigator / Supervisor
Professor Peter Walter Andrews
Co-Investigators /
Co-Supervisors
Dr Jonathan Draper
Institution
University of Sheffield
Department
Biomedical Science
Funding type
Research
Value (£)
195,348
Status
Completed
Type
Research Grant
Start date
21/03/2003
End date
20/06/2006
Duration
39 months
Abstract
We will study established lines of human embryonic stem (hES) cells to elucidate the mechanisms that control the balance between their self-renewal and differentiation. We will use RNA interference and other techniques to study the signalling pathways operating in undifferentiated hES cells, determining whether the LIF/gp130 signalling system operating through STAT3 and ERK plays a role in hES cell self-renewal, and whether other endogenously controlled genes characteristically expressed in hES cells (e.g. Oct4, Rex1(ZFP- 42- and FGF4) also play a role. We will also seek to identify the factor from conditioned medium from mouse embryonic fibroblasts which supports the self-renewal of human ES cells, and prevents their differentiation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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