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The basis of early patterning in the mouse
Reference
G17886
Principal Investigator / Supervisor
Professor Sir Richard Gardner
Co-Investigators /
Co-Supervisors
Institution
University of Oxford
Department
Zoology
Funding type
Research
Value (£)
158,916
Status
Completed
Type
Research Grant
Start date
16/06/2003
End date
15/06/2006
Duration
36 months
Abstract
The basis of the patterning information that is established before the onset of cleavage in the mouse, and which has been implicated in specifying axes of the fetus, will be investigated. Possible involvement of the fertilising sperm will be examined by comparing concepts produced by fertilisation versus parthenogenetically. Whether onset of patterning is associated with activation-induced cytoplasmic rearrangements in the egg and whether its deployment is localised and relates to recently discovered differential orientation of division planes during second cleavage will also be examined, as well as the tissue of the blastocyst in which its role in embryonic axis formation is initiated.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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