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Demographic effects on neutral and selected genome variability in Drosophila melanogaster D.simulans and D.yakuba

Reference	G17575
Principal Investigator / Supervisor	Professor Brian Charlesworth
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	Inst of Cell, Animal and Population Biol
Funding type	Research
Value (£)	187,324
Status	Completed
Type	Research Grant
Start date	30/09/2002
End date	29/12/2005
Duration	39 months

Abstract

Evolutionary processes, such as natural selection for adaptation, can be inferred from patterns of DNA sequence variability in population samples. A problem encountered when making such inferences is that purely non-adaptive processes (e.g. population size changes) can mimic many forms of selection. We will assess to what extent genome-wide nucleotide diversity patterns in D. melanogaster and D. simulans are partitioned by geographic locality and compare these patterns to D. yakuba, an outgroup taxa with a more stable demographic history. This comparative population genetics approach will provide a better point of departure from which to assess the relative impact of selection and demography on patterns of genome variability and evolution.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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