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Plant formins: analysis of a role in plant development and cytoskeletal organisation

Reference	G17542
Principal Investigator / Supervisor	Professor P Hussey
Co-Investigators / Co-Supervisors	Professor Brendan Davies, Dr Michael Deeks
Institution	Durham University
Department	Biological and Biomedical Sciences
Funding type	Research
Value (£)	210,236
Status	Completed
Type	Research Grant
Start date	01/05/2002
End date	01/05/2005
Duration	36 months

Abstract

The position of FORMIN within the pathways governing cell morphology provides a link between plant developmental biology and the plant cytoskeleton. We have the first plant formin knockout mutant resulting from a T-DNA insertion in the FHP7 gene. The fhp7 mutant phenotype is characterised by defects in cell expansion epitomised by the suppression of root hair initiation and elongation. Plant formin structure is unique and they are the only conserved poly-L proline class of profilin binding proteins in plants. We detail methods to identify FHP7 interacting proteins and propose further characterisation of these proteins. We propose genetic approaches to identify modifiers of fhp7, which will lead to new insights into FHP7 gene regulation and FHP function. Moreover, we target other formin genes for knockout by searching for other insertion mutants and or by RNAi. We detail a programme which should lead to establishing a link between development cues and plant cell morphogenesis mediated by cytoskeletal reorganisation.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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