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Investigation of beta-catenin/Lef-1 regulation and function during myogenic specification in chick embryos
Reference
G17536
Principal Investigator / Supervisor
Professor Andrea Munsterberg
Co-Investigators /
Co-Supervisors
Institution
University of East Anglia
Department
Biological Sciences
Funding type
Research
Value (£)
190,552
Status
Completed
Type
Research Grant
Start date
12/08/2002
End date
12/08/2005
Duration
36 months
Abstract
We are interested in events downstream of muscle inductive cues Shh and Wnt-1 in chick embryos. In particular we will investigate the role of so called canonical Wnt pathway which goes through beta-catenin in specification of skeletal muscle; beta-catenin seems to be crucial for early myogenesis and we will interfere with the function of beta-catenin and Lef-1 mediated signals and examine the effects on the myogenic differentiation programme. We have shown previously that Shh, Wnt-1 and Bmp-4 signals converge to control high levels of beta-catenin expression in dermomyotomal lip and myotome. In order to answer whether these signals act directly we will clone and characterise the chick beta-catenin promoter and identify regulatory elements using the recently developed technique of electroporation into chick embryos.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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