Award details

Investigation of the role of a 5'-3' exoribonuclease of Drosophila and C. elegans development

Reference	G16929
Principal Investigator / Supervisor	Professor Sarah Newbury
Co-Investigators / Co-Supervisors
Institution	University of Oxford
Department	Biochemistry
Funding type	Research
Value (£)	220,216
Status	Completed
Type	Research Grant
Start date	10/06/2002
End date	09/05/2004
Duration	23 months

Abstract

Ribonucleases are key factors in the control of mRNA degradation, which is an important, but poorly understood aspect of gene regulation. We have shown that mutations in a gene encoding a 5'-3' exoribonuclease has specific effects on Drosophila embryonic development and that disruption of the expression of the homologous gene in C. elegans by RNA interference results in embryonic development arrest. We will use both genetic and post-genomic approaches to analyse the function of this ribonuclease during development. The specific targets of this ribonuclease and its interactions with other cellular components will also be investigated.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

G16929/2 Investigation of the role of a 5'-3' exoribonuclease of Drosophila and C. elegans development

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