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Investigating the role of Gli3 in development of the telencephalon using nested cre-loxP gene targeting
Reference
G16924
Principal Investigator / Supervisor
Professor John Mason
Co-Investigators /
Co-Supervisors
Professor David Price
Institution
University of Edinburgh
Department
Biomedical Sciences
Funding type
Research
Value (£)
415,320
Status
Completed
Type
Research Grant
Start date
01/11/2002
End date
01/11/2005
Duration
36 months
Abstract
The transcription factor Gli3 is essential for the normal development of the mammalian forebrain. At present, its detailed mechanism of action is not understood. We propose to use cre-loxP gene targeting to generate a series of mutants in which Gli3 is specifically deleted in a nested series of dorsoventral domains of the developing telencephalon. Detailed molecular and histological analysis of these mutants will allow us to determine how Gli3 contributes to dorsoventral patterning of the telencephalon and unravel roles of Gli3 in differentiation and lamination of the cerebral cortex.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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