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Role of Par genes in early mouse development
Reference
G16920
Principal Investigator / Supervisor
Professor Magdalena Zernicka-Goetz
Co-Investigators /
Co-Supervisors
Professor David Glover
Institution
University of Cambridge
Department
Genetics
Funding type
Research
Value (£)
340,908
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
28/02/2006
Duration
50 months
Abstract
Asymmetrically localised Par proteins regulate cell and embryo polarity in several organisms. We will localise the murine Par proteins during meiosis and preimplantation development in relation to the development of cellular and embryonic polarity. We will determine whether such patterns are re-established in embryos recovering from perturbation of their developing body pattern. We will determine how embryonic polarity is affected by overexpressing the Par genes, or by eliminating their function using dsRNAi or dominant negative mutants. Finally, we will study the role of one of the Par-1 like kinases, associating with condensing chromosomes, in relation to mitotic entry and establishment of structure and orientation of the spindle.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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