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Functional characterisation of the Arabidopsis transcriptional regulator LEUNIG
Reference
G16919
Principal Investigator / Supervisor
Professor Robert Conlan
Co-Investigators /
Co-Supervisors
Institution
Swansea University
Department
Biological Sciences
Funding type
Research
Value (£)
188,676
Status
Completed
Type
Research Grant
Start date
10/06/2002
End date
09/09/2005
Duration
39 months
Abstract
Regulation of homeotic gene expression is critical for proper developmental patterns in plants. The Arabidopsis thaliana floral homeotic gene AGAMOUS is regulated by LEUNIG (LUG). Mutations in LUG result in homeotic transformations of floral organ identity, and cause other phenotypic abnormalities suggesting LUG has a wider role in development. LUG is structurally similar to the transcription co-repressors Tup1 (S. cerevisiae), Groucho (Drosophila) and COP1 (A. thaliana) suggesting developmental pathways regulated by LUG may be controlled by a conserved eukaryotic repression mechanism. We will investigate LUG transcription repression mechanisms to further understand floral development in plants, and to determine other targets of LUG regulation.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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