Award details

Genomic microarrays to examine chromosome rearrangement and evolution

Reference	G16891
Principal Investigator / Supervisor	Dr Paul Edwards
Co-Investigators / Co-Supervisors	Professor Carlos Caldas, Dr Sara Melville, Dr David Sargan
Institution	University of Cambridge
Department	Pathology
Funding type	Research
Value (£)	217,584
Status	Completed
Type	Research Grant
Start date	09/09/2002
End date	08/09/2005
Duration	36 months

Abstract

Chromosome rearrangements are crucial in cancer and speciation. They can be mapped rapidly using genomic (not cDNA) microarrays, by isolating chromosomes and hybridizing them to arrayed genomic clones. This proposal brings together 3 programmes using this technology (on human, dog & cat, and trypanosome chromosomes) to create a centre of excellence for genomic microarrays. The proposal's components are to 1) develop and produce genomic arrays, particularly novel plasmid genomic arrays that reduce hybridization complexity; 2) mapping chromosome translocation breakpoints in major human cancers; 3) refine the genomic maps of dog and cat, by mapping on human; 4) map canine chromosomes using arrays; and 5) map the variable chromosomes of trypanosomes.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search