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The roles of insulin/IGF and TOR signalling in ageing and fecundity in Drosophila

Reference	G16872
Principal Investigator / Supervisor	Professor Linda Partridge
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Genetics Evolution and Environment
Funding type	Research
Value (£)	271,112
Status	Completed
Type	Research Grant
Start date	25/03/2002
End date	24/02/2006
Duration	47 months

Abstract

The aim of the project is to understand the roles of insulin/IGF signalling (IIS) and TOR signalling and their regulation by nutrition in the determination of fecundity and rate of ageing in Drosophila. We shall address three questions: (a) How do the systemic and cellular components of IIS regulate fecundity and the rate of ageing; (b) How does nutrition influence IIS to regulate ageing and fecundity; and (c) What is the role of dTOR in regulating fecundity and the rate of ageing, and in the responses of these traits to nutrition. The evolutionary conservation of IIS and TOR signalling function over large evolutionary distances means that the results of this project will be of direct relevance to the control of fecundity and the rate of ageing in mammals.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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