Award details

Discovering key retinoid-responsive genes in early development

Reference	G16871
Principal Investigator / Supervisor	Professor Malcolm Maden
Co-Investigators / Co-Supervisors	Dr Emily Gale
Institution	King's College London
Department	Reproductive Health Endocrinology Dev
Funding type	Research
Value (£)	229,684
Status	Completed
Type	Research Grant
Start date	01/02/2002
End date	01/02/2005
Duration	36 months

Abstract

Retinoic acid is an important signalling molecule in various systems of the developing embryo. To discover which gene pathways retinoic acid controls we have established a retinoic acid deficient quail embryonic system thanks to a 1 year BBSRC grant. We now wish to use this system to study the genes involved in the defective development of the hindbrain, spinal cord, limb bud, somites and lateral plate and forebrain. In the latter 4 systems we will examine the expression of known genes in order to determine which are RA-responsive, but in the former system, the hindbrain, we will use differential display between precisely staged presumptive hindbrain segments to discover novel genes involved in hindbrain specification.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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