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High resolution mapping of developmental changes in histone acetylation at the chicken lysozyme locus
Reference
G16866
Principal Investigator / Supervisor
Professor Colyn Crane-Robinson
Co-Investigators /
Co-Supervisors
Professor Constanze Bonifer
,
Dr Alan Thorne
Institution
University of Portsmouth
Department
Sch of Biological Sciences
Funding type
Research
Value (£)
235,996
Status
Completed
Type
Research Grant
Start date
02/01/2002
End date
01/04/2005
Duration
39 months
Abstract
Core histone acetylation is a key element in transcriptional regulation. Expression of the chicken lysozyme gene is upregulated during macrophage development. The complete regulatory unit is contained within a 21kb region but nothing is known of its acetylation status or how this changes during development. A detailed map of core histone acetylation will be obtained by chromatin immunoprecipitation assays using cell lines representing several developmental stages. The results will be correlated with changes in chromatin structure, in particular at enhancers and the silencer, and with cofactor recruitment to the locus determined in separate experiments.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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