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The role of emx genes in the development of the cerebral cortex
Reference
G16857
Principal Investigator / Supervisor
Professor John Parnavelas
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Cell and Developmental Biology
Funding type
Research
Value (£)
195,500
Status
Completed
Type
Research Grant
Start date
01/04/2002
End date
31/01/2006
Duration
46 months
Abstract
Emx1 and Emx2 are members of the empty spiracles family of genes that are expressed in the developing forebrain including the cerebral cortex. Little is known about the function of these genes in the formation and maturation of the cortex. We propose to use mutant mice in a series of experiments aimed to identify changes in the neuronal composition and connectivity in the cortex of these animals. We shall also trace the migration of the two main neuronal cell types, the pyramidal and nonpyramidal neurones, from their sites of origin to their positions in the cortex. These studies will enhance our understanding of the mechanisms involved in the generation and migration of the neurons of the cortex and the establishment of connections.
Summary
unavailable
Committee
Closed Committee - Genes & Developmental Biology (GDB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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