Award details

Novel methods and software to fine-map QTL in outbred populations

Reference	G16847
Principal Investigator / Supervisor	Dr Sara Knott
Co-Investigators / Co-Supervisors
Institution	University of Edinburgh
Department	Inst of Cell, Animal and Population Biol
Funding type	Research
Value (£)	265,940
Status	Completed
Type	Research Grant
Start date	12/12/2001
End date	01/04/2005
Duration	40 months

Abstract

The research aim is to develop statistical methodology and user-friendly software to fine-map quantitative trait loci (QTL) in outbred populations. Advanced methods combining linkage and linkage disequilibrium regression and maximum likelihood approaches to fine-map QTL in single outbred populations and populations derived from two or more distinct inbred or outbred founder lines will be investigated using analytical methods and computer stimulation. We will develop a graphical user workbench to provide access to the QTL mapping applications and display tools being developed as part of the project. This software will be made available to the UK research community via the world-wide web, and is a logical extension of a BBSRC funded successful implementation of software to map QTL using simple pedigrees in populations derived from inbred and outbred lines (http://latte.cap.ed.ac.uk/). Such powerful but user-friendly software will be essential to fully capitalise upon data from high-density genome scans.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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